Light Chain Myeloma
نویسندگان
چکیده
منابع مشابه
Serum Free Light-chain Assay for the Diagnosis, Management, and Prognosis of Multiple Myeloma
In recent decades, new serum biomarkers have been developed for routine laboratory practice, such as assaying serum free light chains and more recently, assaying immunoglobulin heavy and light chain isotypes (Hevylite). In this work, we highlight the interest of new biomarkers (Hevylite Test) in the management of monoclonal gammopathies because of the technical advantages it confers and the se...
متن کاملDiagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests.
This study aims to guide the integration of serum free light chain (sFLC) tests into clinical practice, including a new rapid test (Seralite® ). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified 576 light chain only (LCO) and 60 non-secretory (NS) cases. Serum was tested by Freelite® and Seralite® at diagnosis, maximum response and relapse. 20% of LCO patients had u...
متن کامل[Biclonal light chain gammopathy in multiple myeloma--a case report].
A 74-year-old woman was admitted to our hospital in March 1998 for low-back pain. In 1990, she had a chemotherapy for diffuse mixed cell lymphoma. Biochemical and serologic assays revealed a total protein level of 9.7 g/dl and an IgG level of 4,530 mg/dl. Immunoelectrophoresis showed monoclonal IgG protein associated with two monoclonal kappa and lambda light chain components. Bone marrow exami...
متن کاملAmyloid light-chain amyloidosis, myeloma and autonomic neuropathy
Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary presenting complaint was of lon...
متن کاملIgD myeloma protein with "unreactive" light chain determinants.
Serum from a patient with multiple myeloma showed a monoclonal protein, classified by immunoelectrophoresis as IgD. Immunofixation electrophoresis and immunoelectrophoresis failed to demonstrate a precipitation reaction between the paraprotein and antisera to immunoglobulin light chains. The light chains of the monoclonal protein, immunologically inaccessible in the intact molecule, reacted wit...
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ژورنال
عنوان ژورنال: The Journal of Kartal Training and Research Hospital
سال: 2013
ISSN: 1302-485X
DOI: 10.5505/jkartaltr.2013.60352